Objective To investigate the effect of paclitaxel on the intimal proliferation in rat aortic allografts and the possible mechanism on preventing graft arteriosclerosis. 目的观察紫杉醇对同种大鼠移植动脉的影响,探讨紫杉醇对移植物动脉硬化的抑制作用及机制。
Serious and diffuse intimal proliferation leading to arterial stenosis and transplanted organ ischemic function failure is the main expression. Therefore, allograft arteriosclerosis has been kept the focus of study in recent years. 其表现为严重的、弥漫性的血管内膜增生,血管腔逐渐狭窄,最终导致移植器官缺血性功能衰竭,因此移植物动脉硬化是近年来人们研究的热点。